Magnesium and Zinc
and the Immune System

Zinc works to maintains and support the activity of key immune cells like infection-fighting T-lymphocyte cells, neutrophils, NK cells, and macrophages.*

Zinc is crucial to many antioxidant enzymes, including glutathione peroxidase and superoxide dismutase: a potent antioxidant and powerful anti-inflammatory.*

Maintaining a healthy sleep cycle is critical to immune health.

Magnesium helps to promote deep, restful sleep in part by maintaining healthy GABA levels.

This is a natural process, helping to support the body’s ability to signal when it is time to sleep, and to help it stay asleep without grogginess the next morning.*

Magnesium is required for the synthesis of the powerful antioxidant glutathione, and may help to reduce C-reactive protein, and inflammation.*

Healthy magnesium levels are required for the bioactivation of vitamin D.

Vitamin D supplementation can lead to lowered magnesium levels as magnesium is used in so many processes involved in the body's utilization of vitamin D.*

Vitamin D is another critical nutrient for immune system function.*

Beyond the Bullet Points

Dig into the literature surrounding essential minerals magnesium and zinc and immune health. 

Fraker, P. J., King, L. E., Laakko, T., & Vollmer, T. L. (2000). The dynamic link between the integrity of the immune system and zinc status. The Journal of nutrition, 130(5), 1399S-1406S. Link  

Fraker, P. J., & King, L. E. (2004). Reprogramming of the immune system during zinc deficiency. Annu. Rev. Nutr., 24, 277-298. Link  

Gammoh, N. Z., & Rink, L. (2017). Zinc in infection and inflammation. Nutrients, 9(6), 624. 

Haase, H., & Rink, L. (2009). Functional significance of zinc-related signaling pathways in immune cells. Annual review of nutrition, 29, 133-152. 

Ibs, K. H., & Rink, L. (2003). Zinc-altered immune function. The Journal of nutrition, 133(5), 1452S-1456S.

Murakami, M., & Hirano, T. (2008). Intracellular zinc homeostasis and zinc signaling. Cancer science, 99(8), 1515-1522. Link

Martinez-Estevez, N. S., Alvarez-Guevara, A. N., & Rodriguez-Martinez, C. E. (2016). Effects of zinc supplementation in the prevention of respiratory tract infections and diarrheal disease in Colombian children: A 12-month randomised controlled trial. Allergologia et immunopathologia, 44(4), 368-375. Link 

National Institutes of Health. (2016). Magnesium Fact Sheet for Health Professionals. Version current, 27.

Prasad, A. S. (2013). Discovery of human zinc deficiency: its impact on human health and disease. Advances in nutrition, 4(2), 176-190. Link  

Prietl, B., Treiber, G., Pieber, T. R., & Amrein, K. (2013). Vitamin D and immune function. Nutrients, 5(7), 2502-2521.

Reddy, P., & Edwards, L. R. (2019). Magnesium supplementation in vitamin D deficiency. American journal of therapeutics, 26(1), e124-e132. 

Rerksuppaphol, S., & Rerksuppaphol, L. (2013). A randomized controlled trial of chelated zinc for prevention of the common cold in Thai school children. Paediatrics and international child health, 33(3), 145-150. Link 

Roohani, N., Hurrell, R., Kelishadi, R., & Schulin, R. (2013). Zinc and its importance for human health: An integrative review. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, 18(2), 144. 

Tapiero, H., & Tew, K. D. (2003). Trace elements in human physiology and pathology: zinc and metallothioneins. Biomedicine & Pharmacotherapy, 57(9), 399-411. 

Uwitonze, A. M., & Razzaque, M. S. (2018). Role of magnesium in vitamin D activation and function. J Am Osteopath Assoc, 118(3), 181-189. Link  

Vakili, R., Vahedian, M., KHODAEI, G. H., & Mahmoudi, M. (2009). Effects of zinc supplementation in occurrence and duration of common cold in school aged children during cold season: a double-blind placebo-controlled trial. Link